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Kazutoshi Mori

Kazutoshi Mori

2014 Albert Lasker Basic Medical Research Award
Intro

Kazutoshi Mori is a Japanese molecular biologist known for research on unfolded protein response. He is a professor of Biophysics at the Graduate School of Science, Kyoto University, and shared the 2014 Albert Lasker Basic Medical Research Award with Peter Walter for discoveries concerning the unfolded protein response - an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and signals the nucleus to carry out corrective measures.

Education and Work Experience
  • 1985, PhD in Pharmaceutical Sciences, Kyoto University
  • 1985- 1989, Gifu Pharmaceutical University, assistant professor
  • 1989-1993, the University of Texas Southwestern Medical Center, postdoctoral fellow
  • 1993-1999, the HSP (Heat Shock Protein) Research Institute, researcher1999-Prsent, Kyoto University, professor of Biophysics
Honors and Awards
    • 2005, Wiley Prize in Biomedical Sciences
    • 2014, Shaw Prize in Life Science and Medicine
    • 2014, Albert Lasker Basic Medical Research Award
    • 2018, Breakthrough Prize in Life Sciences

Major Academic Achievements

The work of Kazutoshi Mori and Peter Walter reveals the unfolded protein response pathway, which explains the mechanism how the cells signal and regulate under pressure. They discovered the signaling molecule Ire1 in 1993, which communicates the state of the endoplasmic reticulum protein production line. This research laid the foundation for the prevention and treatment of many diseases.