He is a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa. Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.
Avram Hershko, Aaron Ciechanover and Irwin Rose, they have made outstanding achievements in the study of cell-controlled protein movement. Their research in DNA repair and control and treatment of human diseases are of great significance. In fact, their result is to discover an important mechanism of protein "death". They have pioneered the process of how human cells control a certain protein, specifically the "waste disposal" process of human cells for unwanted proteins.