Joachim Frank is a German-born American biophysicist at Columbia University, who won the Nobel Prize in Chemistry in 2017 for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.
The primary tool for Frank group’s studies is visualization by cryo-electron microscopy (cryo-EM) combined with single-particle reconstruction. Since samples such as proteins have many different orientations on a cryo-electron microscope grid, it is impossible to determine high resolution structures of protein like X-ray crystal diffraction technology. In order to solve this problem, Professor Frank developed the image analysis technology of single-particle reconstruction. In addition, Professor Frank and his group developed a software called SPIDER (System for Processing Image Data from Electron microscopy and Related fields), which is widely used in the field of protein structure determination with cryo-electron microscopy. Based on the above-described methods of cryo-EM, he and his group made important contributions to structural and functional studies of ribosome in bacteria and eukaryotes.