Protein plays a key role in life activities. Ribosomes are molecular machines for protein synthesis in organisms.
Professor Yonath focused on the X ray crystallography of ribosomes, determined the high-resolution three-dimensional structure of the ribosome, confirmed the channel of the new protein synthesis, and found the universal symmetric region to guide the polypeptides polymerization process, and revealed the extension capture (elongation arrest) in the process of the ribosome synthesis protein. The dynamic process of gating, intracellular regulation, and transportation of protein nascent chains elucidates the mechanism of protein synthesis. In order to carry out the crystallographic study of ribosomes, Professor Yonath pioneered the establishment of cryogenic crystallography, which is now widely used in structural biology for some complex research projects.